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NT2F25 congress, the 21th International Conference on New Trends in Fatigue and Fracture, aims to be an event for sharing recent research on fatigue and fracture mechanics and for identifying current trends and perspective challenges in the field. The development of new materials, including bio-materials, new production processes and new fields of applications requires the introduction of advanced modeling tools and experimental techniques capable of capturing the mechanical behavior at different length scales from the macro- to the nano-scale. Also, the development of novel industrial applications demands the consideration of reliability and integrity aspects under new scenarios. In this context the NT2F25 conference aims at establishing a fruitful place for sharing expertise, thoughts and perspectives on emerging engineering challenges.